Actin assembly: never forget rate constants

Eggs never forget

part of the blame for this age-related decline belongs to lazy stem cells that sit idly by rather than repair injuries. Normally, injuries to muscle tissue activate the stem cell-like satellite cells, which then multiply and differentiate into myoblasts that can fuse with and thus repair injured muscle fibers. The injury-induced proliferation is a function of the Notch pathway. But Rando's grou...

Never forget basics.

To cite: Satya Prakash MVS, Lata S, Badhe ASR. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016218340 DESCRIPTION A patient with open fracture of both bones of a leg was posted for wound debridement and external fixation. L3–L4 space was identified by the loss of resistance technique with Tuohy’s needle. An epidural catheter was passed through the Tuohy’s need...

'I'll never forget what's-his-name'?

Number 9 Most of us have a special respect for people with super-memories. Ancient Chinese schoIars were often ranked and esteemed according to the number of idiographs they memorized. Talmudic scholars were respected for memorizing extensive passages of religious works. I have known people who seem to have a " photographic " memory, although scientists believe that no such thing exists. 1 When...

You never forget your first time.

Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments

I measured the rate of elongation at the barbed and pointed ends of actin filaments by electron microscopy with Limulus sperm acrosomal processes as nuclei. With improvements in the mechanics of the assay, it was possible to measure growth rates from 0.05 to 280 s-1. At 22 degrees C in 1 mM MgCl2, 10 mM imidazole (pH 7), 0.2 mM ATP with 1 mM EGTA or 50 microM CaCl2 or with EGTA and 50 mM KCl, t...